Abstract Disorders of consciousness (DoC) are associated with large-scale alterations in brain dynamics, yet the structural factors that constrain these changes remain unclear. Here, we investigate how the topology of the structural connectome shapes the sensitivity of brain dynamics to perturbation using a whole-brain computational model constrained by diffusion MRI-derived connectivity. We...
Sleep onset is characterized by a departure from arousal, and can be separated into well-differentiated stages: NREM (which encompasses three substages: N1, N2 and N3) and REM (Rapid Eye Movement). Awake brain dynamics are maintained by various wake-promoting mechanisms, particularly the neuromodulators Acetylcholine (ACh) and Noradrenaline (NA), whose levels naturally decrease during the...
While subcellular components of cognition and affectivity that involve the interaction between experience, environment, and physiology -such as learning, trauma, or emotion- are being identified, the physical mechanisms of phenomenal consciousness remain more elusive. We are interested in exploring whether ancient, simpler organisms such as nematodes have minimal consciousness. Is there something...