Jonathan Sperry: research papers - The Consciousness Library

Synthetic studies toward the marine alkaloid convolutindole A, a structurally remarkable derivative of the hallucinogen N,N-Dimethyltryptamine (DMT)

Tetrahedron Letters September 13, 2023 Karen Ichikawa, Jessica C. Neville, Yihan Yu et al. 3 citations

Herein we report the results of a synthetic strategy toward the marine alkaloid convolutindole A, a structurally remarkable derivative of the hallucinogen N,N-dimethyltryptamine (DMT). While attempts to forge an advanced tryptamine intermediate using the Fischer reaction were unsuccessful, an iterative C-H functionalisation strategy proved more fruitful. Subjecting 6-bromoindole to an...

DOI: 10.1016/j.tetlet.2023.154756

Alkaloids from the entheogenic plant Peganum harmala

Australian Journal of Chemistry July 17, 2023 Daniel G. Anstis, Jessica Liyu, Emma K. Davison et al. 8 citations

Entheogenic natural products (e.g., psylocybin and dimethyltryptamine) are emerging as effective therapeutics to treat debilitating mood disorders that are unresponsive to conventional treatment. The detailed evaluation of psychotropic plants will conceivably lead to the discovery of structurally distinct entheogens that may offer improved or complementary medicinal properties to the classic...

DOI: 10.1071/ch23038

Bioinspired total synthesis and structural revision of yuremamine, an alkaloid from the entheogenic plant Mimosa tenuiflora

Chemical Communications 2015 Matthew B. Calvert, Jonathan Sperry 37 citations

A bioinspired synthetic approach to nominal yuremamine has uncovered the true structure of the natural product to be a flavonoidal indole.

DOI: 10.1039/c5cc00380f

Papers

Synthetic studies toward the marine alkaloid convolutindole A, a structurally remarkable derivative of the hallucinogen N,N-Dimethyltryptamine (DMT)

Alkaloids from the entheogenic plant Peganum harmala

Bioinspired total synthesis and structural revision of yuremamine, an alkaloid from the entheogenic plant Mimosa tenuiflora