Psychophysiology
September 10, 2019
Sherain Harricharan, A. Nicholson, J. Thome et al.
Individuals with post-traumatic stress disorder (PTSD) typically experience states of reliving and hypervigilance; however, the dissociative subtype of PTSD (PTSD+DS) presents with additional symptoms of depersonalization and derealization. Although the insula is critical to emotion processing, its association with these contrasting symptom profiles is yet to be fully delineated. Accordingly,...
Frontiers in Human Neuroscience
May 1, 2018
Daniela Rabellino, Dalila Burin, Sherain Harricharan et al.
55 citations
Traumatic experiences have been linked to the development of altered states of consciousness affecting bodily perception, including alterations in body ownership and sense of agency, the conscious experience of the body as one’s own and under voluntary control. Severe psychological trauma and prolonged distress may lead to posttraumatic stress disorder (PTSD).Together, symptoms of derealization...
Human Brain Mapping
December 20, 2017
Daniela Rabellino, Maria Densmore, Sherain Harricharan et al.
64 citations
The bed nucleus of the stria terminals (BNST) is a subcortical structure involved in anticipatory and sustained reactivity to threat and is thus essential to the understanding of anxiety and stress responses. Although chronic stress and anxiety represent a hallmark of post-traumatic stress disorder (PTSD), to date, few studies have examined the functional connectivity of the BNST in PTSD. Here,...
Human Brain Mapping
November 13, 2017
Isadora Olivé, Maria Densmore, Sherain Harricharan et al.
45 citations
OBJECTIVES: The innate alarm system (IAS) models the neurocircuitry involved in threat processing in posttraumatic stress disorder (PTSD). Here, we investigate a primary subcortical structure of the IAS model, the superior colliculus (SC), where the SC is thought to contribute to the mechanisms underlying threat-detection in PTSD. Critically, the functional connectivity between the SC and other...
Neuropsychologia
November 1, 2017
Sherain Harricharan, Andrew A Nicholson, Maria Densmore et al.
64 citations
The vestibular system integrates multisensory information to monitor one's bodily orientation in space, and is influenced by interoceptive awareness. Post-traumatic stress disorder (PTSD) involves typically alterations in interoceptive and bodily self-awareness evidenced by symptoms of hyperarousal, as well as of emotional detachment, including emotional numbing, depersonalization, and...
European Journal of Psychotraumatology
2016
Daniela Rabellino, Sherain Harricharan, Paul Frewen et al.
25 citations
Early traumatic experiences are thought to be causal factors in the development of trauma-related dissociative experiences, including depersonalization and derealization. The rubber hand illusion (RHI), a well-known paradigm that measures multi-sensorial integration of a rubber hand into one's own body representation, has been used to investigate alterations in the experience of body ownership...