Proceedings of the National Academy of Sciences of the United States of America
May 28, 2024
Elie Adam, Marek Kowalski, Oluwaseun Akeju et al.
30 citations
Ketamine is an N-methyl-D-aspartate (NMDA)-receptor antagonist that produces sedation, analgesia, and dissociation at low doses and profound unconsciousness with antinociception at high doses. At high and low doses, ketamine can generate gamma oscillations (>25 Hz) in the electroencephalogram (EEG). The gamma oscillations are interrupted by slow-delta oscillations (0.1 to 4 Hz) at high doses....
Nature Communications
March 29, 2023
Fangyun Tian, Laura D. Lewis, David W. Zhou et al.
63 citations
The neural mechanisms underpinning ketamine’s dissociative and antidepressant effects remain poorly understood. Here, the authors analyzed ketamine-induced brain dynamics with intracranial recordings in humans and found that ketamine engages different brain areas in distinct frequency-dependent patterns that may relate to its dissociative and antidepressant effects. Ketamine produces...
bioRxiv Preprint Server
May 2, 2022
Fangyun Tian, Laura D. Lewis, David W. Zhou et al.
preprint
Subanesthetic doses of ketamine produce rapid and sustained anti-depressant effects in patients with treatment-resistant depression. Unfortunately, the usefulness of ketamine as a treatment is limited by its potential for abuse because of psychotropic side effects such as dissociation. Understanding the brain dynamics and the neural circuits involved in ketamine’s effects could lend insight...
Clinical Neurophysiology
October 1, 2021
Shubham Chamadia, Jacob Gitlin, Jennifer Mekonnen et al.
Objective: Ketamine is an anesthetic drug associated with dissociation. Decreased electroencephalogram alpha (8 to 13 Hz) and low-beta (13 to 20 Hz) oscillation power have been associated with ketamine-induced dissociation. We aimed to characterize surface electroencephalogram signatures that may serve as biomarkers for dissociation. Methods: We analyzed data from a single-site, open-label,...
PLoS Computational Biology
August 18, 2021
Sourish Chakravarty, Indie C. Garwood, S. Chakravarty et al.
32 citations
Ketamine is an NMDA receptor antagonist commonly used to maintain general anesthesia. At anesthetic doses, ketamine causes high power gamma (25-50 Hz) oscillations alternating with slow-delta (0.1-4 Hz) oscillations. These dynamics are readily observed in local field potentials (LFPs) of non-human primates (NHPs) and electroencephalogram (EEG) recordings from human subjects. However, a detailed...
PAIN Reports
June 3, 2021
Eunice Y. Hahm, Shubham Chamadia, J. Locascio et al.
6 citations
Ketamine-induced dissociation and analgesia are independent and robust to general anesthesia neural circuit alterations, suggesting that ketamine can be refined into a targeted pain therapeutic. Abstract Introduction: Ketamine, an anesthetic adjunct, is routinely administered as part of a balanced general anesthetic technique. We recently showed that the acute analgesic and dissociation...
medRxiv
November 16, 2020
Indie C. Garwood, S. Chakravarty, Jacob Donoghue et al.
preprint
Abstract Ketamine is an NMDA receptor antagonist commonly used to maintain general anesthesia. At anesthetic doses, ketamine causes bursts of 30-50 Hz oscillations alternating with 0.1 to 10 Hz oscillations. These dynamics are readily observed in local field potentials (LFPs) of non-human primates (NHPs) and electroencephalogram (EEG) recordings from human subjects. However, a detailed...
Anesthesiology
September 4, 2020
Jacob Gitlin, Shubham Chamadia, J. Locascio et al.
48 citations
Background: Ketamine is a dissociative anesthetic with analgesic properties. Ketamine’s analgesic properties have been suggested to result from its dissociative properties. To the authors’ knowledge, this postulate is unsubstantiated. The authors hypothesize that the dissociative and analgesic properties of ketamine are independent. Methods: The authors conducted a single-site, open-label study...
Journal of Affective Disorders
2019
Dawn F. Ionescu, Kate H Bentley, M. Eikermann et al.
179 citations
BACKGROUND Several studies indicate that ketamine has rapid antidepressant effects in patients with treatment-resistant depression (TRD). The extent to which repeated doses of ketamine (versus placebo) reduce depression in the short and long term among outpatients with TRD and chronic, current suicidal ideation remains unknown. METHODS Twenty-six medicated outpatients with severe major...