S. Chakravarty

2 papers in the library · 32 citations · publishing 2020-2021

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A hidden Markov model reliably characterizes ketamine-induced spectral dynamics in macaque local field potentials and human electroencephalograms

PLoS Computational Biology August 18, 2021 Sourish Chakravarty, Indie C. Garwood, S. Chakravarty et al. 32 citations

Ketamine is an NMDA receptor antagonist commonly used to maintain general anesthesia. At anesthetic doses, ketamine causes high power gamma (25-50 Hz) oscillations alternating with slow-delta (0.1-4 Hz) oscillations. These dynamics are readily observed in local field potentials (LFPs) of non-human primates (NHPs) and electroencephalogram (EEG) recordings from human subjects. However, a detailed...

DOI: 10.1371/journal.pcbi.1009280 Full text Ketamine Local field potential Hidden markov model Electroencephalography +5

A hidden Markov model reliably characterizes ketamine-induced spectral dynamics in macaque LFP and human EEG

medRxiv November 16, 2020 Indie C. Garwood, S. Chakravarty, Jacob Donoghue et al. preprint

Abstract Ketamine is an NMDA receptor antagonist commonly used to maintain general anesthesia. At anesthetic doses, ketamine causes bursts of 30-50 Hz oscillations alternating with 0.1 to 10 Hz oscillations. These dynamics are readily observed in local field potentials (LFPs) of non-human primates (NHPs) and electroencephalogram (EEG) recordings from human subjects. However, a detailed...

DOI: 10.1101/2020.11.12.20221366 Full text