Journal of Neural Engineering
June 10, 2025
Daniel Polyakov, P A Robinson, Eli J Müller et al.
2 citations
Objective.Disorders of consciousness (DoC) remain a significant challenge in neurology, with traditional brain stimulation therapies showing limited and inconsistent efficacy across patients. This study presents a novel computational approach grounded in neural field theory for constructing personalized stimulus signals designed to induce healthy-like neural activity patterns in individuals...
Elife
January 5, 2024
Daniel Toker, Eli J Müller, Hiroyuki Miyamoto et al.
21 citations
Consciousness is thought to be regulated by bidirectional information transfer between the cortex and thalamus, but the nature of this bidirectional communication - and its possible disruption in unconsciousness - remains poorly understood. Here, we present two main findings elucidating mechanisms of corticothalamic information transfer during conscious states. First, we identify a highly...
Proceedings of the National Academy of Sciences of the United States of America
November 14, 2023
Brandon R Munn, Eli J Müller, Jaan Aru et al.
Understanding the neurobiological mechanisms underlying consciousness remains a significant challenge. Recent evidence suggests that the coupling between distal-apical and basal-somatic dendrites in thick-tufted layer 5 pyramidal neurons (L5PN), regulated by the nonspecific-projecting thalamus, is crucial for consciousness. Yet, it is uncertain whether this thalamocortical mechanism can support...
Nature Communications
October 27, 2023
Brandon R Munn, Eli J Müller, Vicente Medel et al.
The human brain displays a rich repertoire of states that emerge from the microscopic interactions of cortical and subcortical neurons. Difficulties inherent within large-scale simultaneous neuronal recording limit our ability to link biophysical processes at the microscale to emergent macroscopic brain states. Here we introduce a microscale biophysical network model of layer-5 pyramidal...
Cell Reports
August 29, 2023
Eli J Müller, Brandon R Munn, Michelle J. Redinbaugh et al.
The neurobiological mechanisms of arousal and anesthesia remain poorly understood. Recent evidence highlights the key role of interactions between the cerebral cortex and the diffusely projecting matrix thalamic nuclei. Here, we interrogate these processes in a whole-brain corticothalamic neural mass model endowed with targeted and diffusely projecting thalamocortical nuclei inferred from...