Background Ketamine is a rapid-acting antidepressant that produces acute dissociative symptoms. In routine care, the respective contributions of therapeutic expectations and dissociative symptoms to antidepressant response, and the directionality of their associations with depressive symptom change, remain poorly characterized.
Abstract Sleep helps regulate emotions, but it is still unclear whether -and how- the emotions we experience in dreams contribute to this regulation. To uncover the potential function of dream emotions, we must first understand what they are and how they unfold in dreams. The emotional content of dreams has mostly been studied using post-sleep dream reports, which provide a biased and static...
Background: Facial emotion recognition deficits are well defined in depression but understudied in treatment-resistant depression (TRD). Over the past decades, subanesthetic doses of ketamine have emerged as an effective treatment for TRD, but its effect on affective processing is still little known. Approaches from computational psychiatry, such as sequential evidence sampling models of...