Molecular Psychiatry
2025
Margareth Nogueira, Daiane C Ferreira Golbert, Richardson Menezes et al.
18 citations
Serotonergic psychedelics have potential therapeutic effects in treating anxiety and mood disorders, often after a single dose, and are suggested to have plasticity-inducing action. However, a comprehensive mechanism of action is still lacking. Here, we investigated how a single dose of the short-acting 5-methoxy-N,N-dimethyltryptamine (5-MeO-DMT) acts on gene expression from microdissected...
Scientific Reports
July 14, 2024
Annie C. Souza, Bryan C. Souza, Arthur França et al.
1 citation
The original version of this Article contained an error in Affiliation 6, which was incorrectly given as ‘Brain Network Dynamics Unit, University of Oxford, Oxford, UK.’ The correct affiliation is listed below:
Scientific Reports
May 17, 2024
Annie C. Souza, Bryan C. Souza, Arthur França et al.
7 citations
5-methoxy-N,N-dimethyltryptamine (5-MeO-DMT) is a potent classical psychedelic known to induce changes in locomotion, behaviour, and sleep in rodents. However, there is limited knowledge regarding its acute neurophysiological effects. Local field potentials (LFPs) are commonly used as a proxy for neural activity, but previous studies investigating psychedelics have been hindered by confounding...
Psychedelics
January 25, 2024
Katarina E. Leão
1 citation
Katarina E. Leão, PhD, is an associate professor at the Brain Institute at the Federal University of Rio Grande do Norte, Natal, Brazil. She is vice-coordinator of the postgraduate program in neuroscience (2013–2017 and 2023 – current) and spent 2020 as a visiting professor at the Karolinska Institute/Uppsala University, Sweden. She is head of the Hearing and Neuronal activity lab researching...
Research Square
December 28, 2023
Margareth Nogueira, Daiane C Ferreira Golbert, Richardson Menezes et al.
2 citations
Abstract Serotonergic psychedelics have potential therapeutic effects in treating anxiety and mood disorders, often after a single dose, and are suggested to have plasticity-inducing action. One lesser studied psychedelic, the 5-methoxy-N, N-dimethyltryptamine (5-MeO-DMT), is suggested to have anxiolytic effects yet a comprehensive mechanism of action is still lacking. Here, we investigated the...
Experimental Neurology
April 1, 2020
Jessica Winne, Barbara C Boerner, Thawann Malfatti et al.
34 citations
Salicylate intoxication is a cause of tinnitus and comorbidly associated with anxiety in humans. In a previous work, we showed that salicylate induces anxiety-like behavior and hippocampal type 2 theta oscillations (theta2) in mice. Here we investigate if the anxiogenic effect of salicylate is dependent on age and previous tinnitus experience. We also tested whether a single dose of DMT can...