Translational Psychiatry
January 29, 2026
Rafael V Lima Da Cruz, Rêmullo B. G. De Miranda Costa, Gabriel M. De Queiroz et al.
2 citations
Major depressive disorder (MDD) remains a leading cause of disability worldwide, with current treatments limited by delayed onset and low efficacy. The serotonergic psychedelic N,N-dimethyltryptamine (DMT) has shown rapid antidepressant effects in early clinical studies, yet its mechanisms and efficacy remain poorly characterized in established models of depression. Here, we evaluated the...
Molecular Psychiatry
2025
Margareth Nogueira, Daiane C Ferreira Golbert, Richardson Menezes et al.
18 citations
Serotonergic psychedelics have potential therapeutic effects in treating anxiety and mood disorders, often after a single dose, and are suggested to have plasticity-inducing action. However, a comprehensive mechanism of action is still lacking. Here, we investigated how a single dose of the short-acting 5-methoxy-N,N-dimethyltryptamine (5-MeO-DMT) acts on gene expression from microdissected...
Mol Med
December 19, 2024
Rafael V Lima Da Cruz, Richardson N. Leão, Thiago C. Moulin
13 citations
In the mammalian brain, new neurons continue to be generated throughout life in a process known as adult neurogenesis. The role of adult-generated neurons has been broadly studied across laboratories, and mounting evidence suggests a strong link to the HPA axis and concomitant dysregulations in patients diagnosed with mood disorders. Psychedelic compounds, such as phenethylamines, tryptamines,...
Scientific Reports
July 14, 2024
Annie C. Souza, Bryan C. Souza, Arthur França et al.
1 citation
The original version of this Article contained an error in Affiliation 6, which was incorrectly given as ‘Brain Network Dynamics Unit, University of Oxford, Oxford, UK.’ The correct affiliation is listed below:
Scientific Reports
May 17, 2024
Annie C. Souza, Bryan C. Souza, Arthur França et al.
7 citations
5-methoxy-N,N-dimethyltryptamine (5-MeO-DMT) is a potent classical psychedelic known to induce changes in locomotion, behaviour, and sleep in rodents. However, there is limited knowledge regarding its acute neurophysiological effects. Local field potentials (LFPs) are commonly used as a proxy for neural activity, but previous studies investigating psychedelics have been hindered by confounding...
Research Square
December 28, 2023
Margareth Nogueira, Daiane C Ferreira Golbert, Richardson Menezes et al.
2 citations
Abstract Serotonergic psychedelics have potential therapeutic effects in treating anxiety and mood disorders, often after a single dose, and are suggested to have plasticity-inducing action. One lesser studied psychedelic, the 5-methoxy-N, N-dimethyltryptamine (5-MeO-DMT), is suggested to have anxiolytic effects yet a comprehensive mechanism of action is still lacking. Here, we investigated the...
bioRxiv (Cold Spring Harbor Laboratory)
July 20, 2023
Rafael V Lima Da Cruz, Richardson N. Leão, Thiago C. Moulin
preprint
In the mammalian brain, new neurons continue to be generated throughout life in a process known as adult neurogenesis. The role of adult-generated neurons has been broadly studied across laboratories, and mounting evidence suggests a strong link to the HPA axis and concomitant malfunctions in patients diagnosed with mood disorders. Psychedelic compounds, such as phenethylamines, tryptamines,...
Experimental Neurology
April 1, 2020
Jessica Winne, Barbara C Boerner, Thawann Malfatti et al.
34 citations
Salicylate intoxication is a cause of tinnitus and comorbidly associated with anxiety in humans. In a previous work, we showed that salicylate induces anxiety-like behavior and hippocampal type 2 theta oscillations (theta2) in mice. Here we investigate if the anxiogenic effect of salicylate is dependent on age and previous tinnitus experience. We also tested whether a single dose of DMT can...
Frontiers in Molecular Neuroscience
April 4, 2019
Rafael Vitor Lima Da Cruz, Thiago C. Moulin, Lyvia Lintzmaier Petiz et al.
4 citations
correction
CORRECTION article Front. Mol. Neurosci., 04 April 2019Sec. Molecular Signalling and Pathways Volume 12 - 2019 | https://doi.org/10.3389/fnmol.2019.00079
Frontiers in Molecular Neuroscience
September 4, 2018
Rafael Vitor Lima Da Cruz, Thiago C. Moulin, Lyvia Lintzmaier Petiz et al.
86 citations
The subgranular zone (SGZ) of dentate gyrus (DG) is one of the few regions in which neurogenesis is maintained throughout adulthood. It is believed that newborn neurons in this region encode temporal information about partially overlapping contextual memories. The 5-Methoxy-N,N-dimethyltryptamine (5-MeO-DMT) is a naturally occurring compound capable of inducing a powerful psychedelic state....