Journal of Pharmacology and Experimental Therapeutics
February 2018
William S John, Thomas J Martin, Kiran Kumar Solingapuram Sai et al.
Cannabis-related impairments to cognitive function may represent novel therapeutic targets for cannabis-use disorder, although the nature, persistence, and reversibility of such deficits remain unclear. Adult male rhesus monkeys (N = 6) responded in the morning on tasks designed to assess different cognitive domains using the Cambridge Neuropsychological Test Automated Battery (CANTAB)...
Neuropharmacology
2011
Robert W Gould, H Donald Gage, Matthew L Banks et al.
Cocaine self-administration alters brain dopaminergic and serotonergic function primarily in mesolimbic and prefrontal brain regions whereas 3,4-methylenedioxymethamphetamine (MDMA) self-administration predominately alters brain serotonergic function in a more widespread distribution across cortical regions. We previously reported that, compared to drug-naïve rhesus monkeys, self-administration...
Behavioural Pharmacology
July 2008
Matthew L Banks, Robert W Gould, Paul W Czoty et al.
Concurrent schedules of reinforcement are increasingly being used to investigate the reinforcing strength of abused drugs. A purported advantage of concurrent schedules is that the primary dependent measure, percentage of responses emitted on the drug-associated manipulandum, is independent of the rate-altering effects of drugs. Data supporting this hypothesis are, however, rarely presented,...
Behavioural Pharmacology
March 2008
Matthew L Banks, Paul W Czoty, Jon E. Sprague et al.
In monkeys, elevating ambient temperature has been shown to increase sensitivity to 3,4-methylenedioxymethamphetamine (MDMA) reinforcement. Earlier rodent studies have shown that elevations in thyroid levels (hyperthyroidism) parallel changes in elevating the ambient temperature on MDMA-induced thermogenesis, but the interaction has not been examined in monkeys. This study was designed to...
Psychopharmacology
January 2008
Matthew L Banks, Jon E. Sprague, Paul W Czoty et al.
3,4-Methylenedioxymethamphetamine (MDMA, ecstasy) is frequently used in hot environments, such as rave parties. Studies in laboratory animals have shown that ambient temperature can alter the behavioral and neurochemical effects of MDMA. To examine the influence of ambient temperature on the relative reinforcing strength of MDMA and reinstatement of behavior previously maintained by MDMA is the...
Neuropsychopharmacology
January 2008
Matthew L Banks, Paul W Czoty, H Donald Gage et al.
Although serotonin (5-HT) can interact with dopamine (DA) systems to modulate the subjective and reinforcing effects of psychostimulants such as cocaine and 3,4-methyldioxymethamphetamine (MDMA, ecstasy), the long-term effects of exposure to psychostimulants on brain 5-HT systems are not well characterized. The present study assessed 5-HT transporter (SERT) availability using positron emission...
Drug Metabolism and Disposition
October 2007
Matthew L Banks, Jon E. Sprague, David F Kisor et al.
Changes in ambient temperature are known to alter both the hyperthermic and the serotonergic consequences of 3,4-methylenedioxymethamphetamine (MDMA). Metabolism of MDMA has been suggested to be a requisite for these neurotoxic effects, whereas the hyperthermic response is an important contributing variable. The aim of the present study was to investigate the interaction between ambient...