Standard 8-week Mindful Self-Compassion and Mindfulness-Based Stress Reduction trainings both produced benefits on anxiety, depression, perceived stress, positive and negative affect, and psychological flexibility compared with a control group. These gains were maintained over a year of continuous practice. The two programmes showed a similar trajectory over the measurement periods. The 8-week MSC programme and regular practice of mindfulness and self-compassion appear to be an effective intervention for promoting mental health in the general population, with benefits similar to those from MBSR.
Adolescent rats exposed to vaporized THC, alone or with CBD, showed no significant changes in behavioral traits or alcohol self-administration compared to controls. However, females exhibited a more vulnerable pattern of alcohol consumption and seeking. In THC-exposed males, a negative correlation appeared between sucrose preference and compulsive alcohol seeking; in females, THC disrupted the link between novelty preference and alcohol intake and was associated with a negative correlation between goal-tracking and compulsive seeking. Naltrexone reduced alcohol intake most effectively in THC-exposed rats versus those given a high-CBD/low-THC mixture. Adolescent cannabinoid exposure has limited effects on overall alcohol risk but may alter psychological underpinnings of alcohol-related behaviors and increase naltrexone potency, with sex differences highlighting the need for personalized interventions.