Journal of Psychopharmacology
August 6, 2026
Tijmen P.L. Bostoen, Erwin Krediet, Annette van Schagen et al.
Background: The potential safety and efficacy of the psychedelic 3,4-methylenedioxymethamphetamine-assisted therapy (MDMA-AT) for post-traumatic stress disorder (PTSD) has been researched in phase 2 and phase 3 clinical trials. We examined the occurrence and role of mystical experiences in MDMA-AT. Methods: Data were sourced from two phase 2 randomized trials of MDMA-AT for chronic PTSD, in...
Journal of Psychiatric Research
2026
Ola Hornmoen, Jessica Carlsson, Jesper Dammeyer et al.
A recent randomized controlled trial (RCT) did not find an effect of imagery rehearsal therapy (IRT) for nightmares as an add-on to treatment as usual in a sample of trauma-affected refugees. However, certain factors may have accounted for substantial variations in treatment outcomes. This study aimed to test whether symptom severity, cognitive functioning, use of an interpreter, motivation for...
The International Journal of Neuropsychopharmacology
March 12, 2020
Erwin Krediet, Tijmen Bostoen, Joost J. Breeksema et al.
262 citations
Abstract There are few medications with demonstrated efficacy for the treatment of posttraumatic stress disorder (PTSD). Treatment guidelines have unequivocally designated psychotherapy as a first line treatment for PTSD. Yet, even after psychotherapy, PTSD often remains a chronic illness, with high rates of psychiatric and medical comorbidity. Meanwhile, the search for and development of drugs...
Journal of Sleep Research
January 29, 2019
Annika Gieselmann, Malik Ait Aoudia, Michelle Carr et al.
192 citations
This consensus paper provides an overview of the state of the art in research on the aetiology and treatment of nightmare disorder and outlines further perspectives on these issues. It presents a definition of nightmares and nightmare disorder followed by epidemiological findings, and then explains existing models of nightmare aetiology in traumatized and non-traumatized individuals. Chronic...
Journal of Clinical Psychology
2017
Annette van Schagen, Jaap Lancee, Marijke Swart et al.
Nightmares are associated with psychopathology and impaired coping in the general population. However, little is known about this association in a psychiatric population. In this study, we investigate whether patients with diverse psychiatric disorders have increased symptomatology and different coping styles if they suffer from comorbid nightmare disorder. Participants were 498 patients with...
The Journal of Clinical Psychiatry
September 1, 2015
Annette van Schagen, Jaap Lancee, Izaäk W De Groot et al.
Nightmares are associated with psychopathology and daily distress. They are highly prevalent in a psychiatric population (30%). Currently, imagery rehearsal therapy (IRT) is the treatment of choice for nightmares. With IRT, the script of the nightmare is changed into a new dream, which is imagined during the day. However, the effects of IRT in a psychiatric population remain unknown. The aim of...