Beatriz Aparecida Passos Bismara Paranhos - The Consciousness Library

Predicting drug–drug interactions between ayahuasca alkaloids and SSRIs using physiologically based pharmacokinetic modeling

Frontiers in Molecular Biosciences February 18, 2026 Gabriella de Souza Gomes Ribeiro, Beatriz Aparecida Passos Bismara Paranhos, Fabiane Dörr et al. 1 citation

The findings suggest a clinically relevant interaction between ayahuasca and SSRIs, as even modest increases in DMT exposure may intensify serotonergic effects in individuals receiving antidepressant therapy. This study provides a mechanistic and quantitative framework for assessing interaction risks between ayahuasca alkaloids and SSRIs, supporting clinical decision-making and harm-reduction...

DOI: 10.3389/fmolb.2026.1768402 Ayahuasca Serotonergic Paroxetine Pharmacology +14

A dispersive liquid-liquid microextraction method for the determination of ayahuasca alkaloids (N,N-dimethyltryptamine and β-carbolines) in human hair.

Talanta January 27, 2026 Fabiana Pereira Santos, Beatriz Aparecida Passos Bismara Paranhos, Thaisa Meira Sandini et al.

Ayahuasca, a traditional Amazonian hallucinogenic plant brew once used in healing rituals, is now globally popular, raising safety concerns outside ceremonial contexts. Its compounds, alkaloids, are stimulating scientific interest for their potential antidepressant and anxiolytic effects. In this study, we employed a more sustainable analytical extraction method for the determination of...

DOI: 10.1016/j.talanta.2026.129455 Full text Ayahuasca Dimethyltryptamine Dispersive liquid-liquid microextraction Green analytical toxicology +1

Dimethyltryptamine and harmine, components of ayahuasca, prevented cocaine-induced apoptosis in SH-SY5Y human neuroblastoma cells

Archives of Toxicology November 12, 2025 Gilles Salles, Carolina Aparecida de Faria Almeida, Isabella de Carvalho Alves et al.

Ayahuasca is a psychoactive brew traditionally used in religious rituals by indigenous Amazonian populations and South American syncretic religions such as Santo Daime and União do Vegetal. Its psychoactive effects are primarily due to N,N-dimethyltryptamine (DMT), while harmine (HRE), a β-carboline alkaloid, inhibits monoamine oxidase (MAO), enabling DMT's oral bioavailability. Recent studies...

DOI: 10.1007/s00204-025-04208-8 Ayahuasca Harmine Apoptosis Flow cytometry +13

Ayahuasca prevents the reinstatement of cocaine-induced rewarding effects in C57Bl/6 mice.

Psychopharmacology October 31, 2025 Vítor Bruno, Lídia Emmanuela Wiazowski Spelta, Matheus Lujan Pereira et al.

Ayahuasca is a brew containing the psychedelic compound N,N-dimethyltryptamine (DMT) and β-carbolines, traditionally consumed in indigenous rituals. Recent studies suggest its potential to reduce depression and anxiety and as an alternative for treating ethanol and tobacco use disorders. However, research on its impact on cocaine use disorder remains limited. To analyze the rewarding effects of...

DOI: 10.1007/s00213-025-06946-0 Full text Addiction Ayahuasca Cocaine use disorder Conditioned place preference +2

Ayahuasca prevents the reinstatement of cocaine-induced rewarding effects in C57Bl/6 mice

Research Square July 25, 2025 Vítor Bruno, Lídia Emmanuela Wiazowski Spelta, Matheus Lujan Pereira et al.

Abstract Ayahuasca is a psychedelic brew used for centuries in religious rituals by indigenous cultures. Recent studies suggest its potential to reduce depression and anxiety and as an alternative for treating ethanol and tobacco use disorders. However, research on its impact on cocaine use disorder remains limited. We investigated the effects of ayahuasca on the reinstatement of...

DOI: 10.21203/rs.3.rs-7140966/v1 Full text Ayahuasca Pharmacology

Long-term ayahuasca use is associated with preserved global cognitive function and improved memory: a cross-sectional study with ritual users.

European Archives of Psychiatry and Clinical Neuroscience March 1, 2025 Arilton Martins Fonseca, Rafael Guimarães Dos Santos, Lívia Soman de Medeiros et al. 10 citations

Although several studies have been conducted to elucidate the relationship between psychedelic consumption and cognition, few have focused on understanding the long-term use influence of these substances on these variables, especially in ritualistic contexts. To verify the influence of ritualistic ayahuasca consumption on the cognition of experienced ayahuasca religious users (> 20 years) and...

DOI: 10.1007/s00406-024-01817-9 Full text Banisteriopsis caapi Psychotria viridis Cognition Santo daime +9

Subjective Effects of a Single Dose of Ayahuasca among College Students with Harmful Alcohol Use: Qualitative Analysis of Participant Accounts

Psychoactives November 17, 2023 Anna Beatriz Vicentini, Lucas Silva Rodrigues, Giordano Novak Rossi et al. 4 citations

Alcohol is the recreational drug most frequently consumed, and its high frequency of use can lead to worsening social, psychological, and domestic issues. The age group most susceptible to alcohol dependence is 18- to 24-year-old youths, demanding interventional tools to target early involvement risks. Ayahuasca seems to be a promising therapeutic tool since evidence suggests it presents...

DOI: 10.3390/psychoactives2040022 Ayahuasca Anxiety Addiction Clinical psychology +1

Effects of a Single Dose of Ayahuasca in College Students With Harmful Alcohol Use: A Single-blind, Feasibility, Proof-of-Concept Trial.

Journal of Clinical Psychopharmacology Lucas Silva Rodrigues, José Augusto Silva Reis, Giordano Novak Rossi et al. 8 citations

Ayahuasca is a South American plant hallucinogen rich in the psychedelic N,N-dimethyltryptamine and β-carbolines (mainly harmine). Preclinical and observational studies suggest that ayahuasca exerts beneficial effects in substance use disorders, but these potentials were never assessed in a clinical trial. Single-center, single-blind, feasibility, proof-of-concept study, assessing the effects...

DOI: 10.1097/jcp.0000000000001872 Full text Ayahuasca medicine Psychedelics Addiction treatment Substance abuse +1

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