Frontiers in Neurology
April 23, 2026
Jing Cao, ZiYuan Wang, GeGe Lv et al.
Background Paclitaxel (PTX), a broad-spectrum anti-tumor drug, is extensively employed as a first-line chemotherapy for solid tumors, including lung and breast cancers. However, it induces chemotherapy-related pain and anxiety in over 53% of patients. S-ketamine, the S-enantiomer of ketamine, exerts rapid antidepressant effects. In this study, we established a PTX model to examine the effects...
Behavioral sciences (Basel, Switzerland)
February 24, 2025
Xu Li, Yong Yang, Ranran Wang et al.
Fear acquisition is an essential survival mechanism for humans; however, the role and mechanisms of mindfulness training in this process remain unclear. This study employed a discriminative fear conditioning paradigm to investigate the effects and mechanisms of short-term mindfulness training, exemplified by the breath-counting task, on fear acquisition. The experiment consisted of three...
Neurobiology of Disease
March 1, 2024
Yong Yang, Akifumi Eguchi, Chisato Mori et al.
Depression frequently occurs in patients with liver cirrhosis, yet the reasons for this correlation are not fully understood. Dysbiosis of gut microbiota has been implicated in depression through the gut-brain axis via the vagus nerve. This study explored the potential role of the gut-liver-brain axis via the vagus nerve in depression-like phenotypes in mice with liver cirrhosis. These mice...
Journal of Affective Disorders
January 15, 2024
Yong Yang, Akifumi Eguchi, Xiayun Wan et al.
Depression is a frequent symptom in patients with chronic liver disease; however, the mechanisms underlying this association remain unclear. Dysbiosis of gut microbiota plays a critical role in depression through the gut-brain axis via the vagus nerve. In this study, we investigated whether the gut-microbiota-liver-brain axis plays a role in depression-like phenotypes in mice with hepatic...