Canadian Journal of Pain
March 4, 2026
Nandana D. Parakh, Danielle Lessor, Kevin Dang et al.
Although pain experiences differed among participants, all participants reported decreased pain with ketamine infusions. Addressing the stigma associated with ketamine infusions, further research around augmenting durability of ketamine, and providing a safe treatment environment can all improve ketamine's benefit for chronic neuropathic pain. Understanding the barriers and facilitators, as...
Canadian journal of anaesthesia = Journal canadien d'anesthesie
September 1, 2025
Mindy Lu, Victoria Tucci, Nandana D. Parakh et al.
Emerging evidence suggests that 3,4-methylenedioxymethamphetamine (MDMA)-assisted psychotherapy may be a promising intervention for chronic pain. We designed the Ecstasy for Alleviating Severe Chronic Neuropathic Pain (EASE-Pain) trial, a randomized controlled trial comparing MDMA with an active placebo (methylphenidate) for pain relief. We sought to conduct a prospective preference assessment...
JMIR Mental Health
May 13, 2025
Meysam Pirbaglou, Christo El Morr, Farah Ahmad et al.
2 citations
Mindfulness-based interventions (MBIs) are widely employed in mental health promotion and treatment. Despite widespread evidence of effectiveness with different populations and delivery modes, there are sparse findings concerning the mechanisms of action in MBIs. This study, based on a secondary evaluation of two randomized controlled trials (RCTs) with student participants, was aimed at...
Canadian Journal of Pain
November 8, 2024
Jiwon Lee, Kaylyssa Philip, Hance Clarke et al.
3 citations
The PEACE-PAIN trial study design is supported by patient survey responses but may benefit from modifications, namely incorporating thorough discussions of the current evidence for efficacy, safety, tolerability, and approaches to address adverse effects of psilocybin. Additionally, the interest in participation by individuals with prior psychedelic use holds important methodological...
JMIR Mental Health
June 12, 2024
Camrie Kerry, Prabhdeep Mann, Nazanin Babaei et al.
4 citations
Internet-based cognitive behavioral therapy (CBT) and stand-alone mindfulness meditation interventions are gaining empirical support for a wide variety of mental health conditions. In this study, we test the efficacy of web-based therapist-guided mindfulness-based cognitive behavioral therapy (CBT-M) for body dysmorphic disorder (BDD), a psychiatric disorder characterized by preoccupations with...
JMIR Research Protocols
April 17, 2024
Akash Goel, Bhavya Kapoor, Hillary Chan et al.
2 citations
Chronic pain affects approximately 8 million Canadians (~20%), impacting their physical and mental health while burdening the health care system with costs of upwards of US $60 billion a year. Indeed, patients are often trialed on numerous medications over several years without reductions to their symptoms. Therefore, there is an urgent need to identify new therapies for chronic pain to improve...
Journal of Pain Research
June 1, 2022
Sandra J Drozdz, Akash Goel, Matthew W Mcgarr et al.
2 citations
Sandra J Drozdz,1 Akash Goel,1â 3 Matthew W McGarr,4 Joel Katz,3,5â 7 Paul Ritvo,5,7 Gabriella F Mattina,1 Venkat Bhat,8â 10 Calvin Diep,3 Karim S Ladha1,3,10 1Department of Anesthesia, St. Michaelâs Hospital, Toronto, ON, Canada; 2Department of Anesthesiology, Pain and Perioperative Medicine, Stanford University, Stanford, CA, USA; 3Department of Anesthesiology and Pain Medicine,...
JMIR Mental Health
December 2, 2020
Paul Ritvo, F. Ahmad, Christo El Morr et al.
Background University students are experiencing higher levels of distress and mental health disorders than before. In addressing mental health needs, web-based interventions have shown increasing promise in overcoming geographic distances and high student-to-counselor ratios, leading to the potential for wider implementation. The Mindfulness Virtual Community (MVC) program, a web-based program,...
JMIR Mental Health
June 17, 2020
Christo El Morr, Paul Ritvo, F. Ahmad et al.
Background A student mental health crisis is increasingly acknowledged and will only intensify with the COVID-19 crisis. Given accessibility of methods with demonstrated efficacy in reducing depression and anxiety (eg, mindfulness meditation and cognitive behavioral therapy [CBT]) and limitations imposed by geographic obstructions and localized expertise, web-based alternatives have become...