Journal of Pain Research
2025
Miaomiao Xiong, Yao Liu, Yingsi Liang et al.
6 citations
Enhanced recovery after surgery emphasizes effective analgesia while minimal opioid use. Opioid-free anesthesia (OFA) and opioid-sparing anesthesia (OSA) have been shown to enhance recovery by reducing opioid-induced side effects. This study compared the efficacy of OFA and OSA in managing postoperative pain and recovery after laparoscopic cholecystectomy (LC). A single-center, randomized...
Journal of Pain Research
2025
Wen-Wen Huo, Jia-Yu Qian, Han-Xue Zhao et al.
4 citations
Opioids are widely used for anesthesia and postoperative analgesia; however, their use is related to increased risks of untoward effects including hyperalgesia and chronic postsurgical pain (CPSP). We aim to compare opioid-free anesthesia (OFA) with opioid-based anesthesia (OBA) on the incidence of CPSP after video-assisted thoracoscopic surgery (VATS). This randomized controlled clinical trial...
Journal of Pain Research
2025
Wolf Mehling, Carrie E Brintz, Wendy Hartogensis et al.
4 citations
Mindfulness-Based Stress Reduction (MBSR) has shown efficacy for alleviating chronic low back pain (cLBP) and is included in current treatment guidelines. However, benefits are moderate. We aimed to optimize MBSR for chronic pain by using recent research to develop Mindfulness-Based Pain Reduction (MBPR) and test it in patients with cLBP. Phase 1: We modified the MBSR curriculum with...
Journal of Pain Research
2025
Martha O Kenney, Alexander T Limkakeng, Timothy N Ochoa et al.
1 citation
Vaso-occlusive events (VOEs) are the primary cause of acute pain in individuals with sickle cell disease (SCD), where high-dose opioids are the current standard treatment. Ketamine, a non-opioid analgesic, holds potential for managing acute SCD due to its opioid-sparing properties. This study aimed to explore the barriers and facilitators to an inpatient clinical trial of ketamine infusion for...
Journal of Pain Research
2025
Darren K. Cheng, Robert Simpson, Rahim Moineddin et al.
Chronic pain (CP) often co-occurs with depression, but promising scalable interventions have been under-investigated. We assessed the effectiveness of the virtually-delivered Sahaj Samadhi Meditation (SSM) program in reducing depressive symptoms in people with CP and moderate depressive symptoms. We conducted a randomized controlled trial comparing SSM to the Health Enhancement Program (HEP),...
Journal of Pain Research
2025
Vlodeks Gromakovskis, Mārtiņš Gustavs Gūtmanis
Chronic pain remains one of the leading causes of disability worldwide and is strongly influenced by attentional and cognitive-emotional factors such as catastrophizing and hypervigilance. While distraction techniques (eg, virtual reality, music) and mindfulness-based approaches are established adjuncts in pain management, the psychological construct of flow-a state of deep absorption and...
Journal of Pain Research
March 1, 2024
Christopher L. Robinson, Alexandra Fonseca, Efemena Diejomaoh et al.
32 citations
Psychedelics may have potential in alleviating pain symptoms secondary to a multitude of chronic pain conditions. However, further randomized, double-blind, placebo-controlled trials are needed to further explore and evaluate the role of psychedelics in chronic, non-cancer pain.
Journal of Pain Research
2024
Christopher L. Robinson, Matthew Slitzky, Michael E Schatman et al.
4 citations
Psychedelics, substances with a long history of cultural and medicinal use, are experiencing a resurgence in clinical research, particularly in psychiatry. Despite their classification as Schedule I drugs, recent studies suggest therapeutic potential, particularly in treating refractory depression. With chronic pain representing a major health concern and with few non-opioid treatment options...
Journal of Pain Research
June 1, 2022
Sandra J Drozdz, Akash Goel, Matthew W Mcgarr et al.
2 citations
Sandra J Drozdz,1 Akash Goel,1â 3 Matthew W McGarr,4 Joel Katz,3,5â 7 Paul Ritvo,5,7 Gabriella F Mattina,1 Venkat Bhat,8â 10 Calvin Diep,3 Karim S Ladha1,3,10 1Department of Anesthesia, St. Michaelâs Hospital, Toronto, ON, Canada; 2Department of Anesthesiology, Pain and Perioperative Medicine, Stanford University, Stanford, CA, USA; 3Department of Anesthesiology and Pain Medicine,...
Journal of Pain Research
2022
Alexandra Ferreira-Valente, Benjamin P Van Dyke, Melissa A Day et al.
Previous research supports the usefulness of hypnosis (HYP), mindfulness meditation (MM), and prayer as pain self-management strategies in adults with chronic pain. However, their effects on acute pain have been less researched, and no previous head-to-head study compared the immediate effects of these three approaches on pain-related outcomes. This study compared the immediate effects of HYP,...
Journal of Pain Research
2019
Ulises Coffeen, Francisco Pellicer
33 citations
Salvia divinorum is a herbal plant native to the southwest region of Mexico. Traditional preparations of this plant have been used in illness treatments that converge with inflammatory conditions and pain. Currently, S. divinorum extracts have become popular in several countries as a recreational drug due to its hallucinogenic effects. Its main active component is a diterpene named salvinorin A...