Sarah Gare

2 papers in the library · 9 citations · publishing 2024-2025

Papers

Analytical and Pharmacological Characterization of 1-(Furan-2-Carbonyl)-LSD (1F-LSD) and Comparison With 1-(Thiophene-2-Carbonyl)-LSD (1T-LSD).

Drug Testing and Analysis December 3, 2024 Simon D. Brandt, Pierce V. Kavanagh, Sarah Gare et al. 5 citations

1-(2-furoyl)-lysergic acid diethylamide (1F-LSD, SYN-L-005) is a novel analog of the recently detected recreational drug 1-(thiophene-2-carbonyl)-LSD (1T-LSD). Both substances are N1-acylated LSD derivatives that bind to the 5-HT2A receptor, the primary site of action for psychedelic drugs. In C57BL/6J mice, 1F-LSD and 1T-LSD induced the head-twitch response, a 5-HT2A-mediated behavior, and were hydrolyzed to LSD after administration. These findings indicate that both compounds exhibit LSD-like properties and likely act as prodrugs for LSD, releasing the active drug in the body.

DOI: 10.1002/dta.3829 Full text LSD Research Prodrugs Psychopharmacology Head‐twitch response +3

Analytical and behavioral characterization of 1-hexanoyl-LSD (1H-LSD).

Drug Testing and Analysis April 1, 2025 Simon D. Brandt, Pierce V. Kavanagh, Sarah Gare et al. 4 citations

A newly developed LSD derivative, 1-hexanoyl-LSD (1H-LSD), was characterized analytically and tested in mice using the head-twitch response assay, a behavioral proxy for psychedelic activity. 1H-LSD induced head-twitch responses with a median effective dose of 192.4 μg/kg, making it roughly as potent as the known analog 1A-LSD (ALD-52) under similar conditions. Like other N1-acylated LSD derivatives, 1H-LSD is expected to be hydrolyzed to LSD in the body, acting as a prodrug. It is not yet known whether this compound has appeared on the recreational drug market or in research chemical supplies.

DOI: 10.1002/dta.3767 Full text LSD Psychedelics hallucinogens Acid research Head‐twitch response +6