Editorial: Retuning the Adolescent Brain: Esketamine and Rapid Structural Change in the rACC.
Journal of the American Academy of Child and Adolescent Psychiatry March 17, 2026 Yunjia Liu, Qiang Wang
Adolescent major depressive disorder (MDD) is a leading cause of disability worldwide and a major, modifiable risk factor for suicide, which remains the second leading cause of death in this age group.1 For 30% to 50% of patients who fail to achieve remission despite multiple treatment steps, the clinical and psychosocial consequences are substantial.2 Although selective serotonin-reuptake...