Ibogaine induces glial activation in parasagittal zones of the cerebellum.
Neuroreport March 1, 1993 E O'Hearn, D B Long, M E Molliver 72 citations
Ibogaine, an indole alkaloid, has been proposed for treatment of drug addiction, yet its mechanism, site of action, and possible neurotoxicity have not been determined. Since neuronal injury is known to activate neurologlial cells, we investigated potential neurotoxic effects of this drug in rats by examining expression of specific glial markers. After treatment with ibogaine (100 mg kg-1 i.p.;...