T Emanuelli

Ibogaine alters synaptosomal and glial glutamate release and uptake.

Neuroreport February 12, 2001 M B Leal, T Emanuelli, L D Porciúncula et al. 14 citations

Ibogaine has aroused expectations as a potentially innovative medication for drug addiction. It has been proposed that antagonism of the NMDA receptor by ibogaine may be one of the mechanisms underlying its antiaddictive properties; glutamate has also been implicated in ibogaine-induced neurotoxicity. We here report the effects of ibogaine on [3H]glutamate release and uptake in cortical and...