A dose-response study of ibogaine-induced neuropathology in the rat cerebellum.
Toxicological sciences : an official journal of the Society of Toxicology September 1, 2000 Z Xu, L W Chang, William Slikker et al. 37 citations
Ibogaine (IBO) is an indole alkaloid from the West African shrub, Tabernanthe iboga. It is structurally related to harmaline, and both these compounds are rigid analogs of melatonin. IBO has both psychoactive and stimulant properties. In single-blind trials with humans, it ameliorated withdrawal symptoms and interrupted the addiction process. However, IBO also produced neurodegeneration of...