Effects of noribogaine on the development of tolerance to antinociceptive action of morphine in mice.
Brain Research October 17, 1997 Hemendra N. Bhargava, Ying-Jun Cao 10 citations
The effects of noribogaine, a metabolite of ibogaine, on the development of tolerance to the antinociception action of morphine was determined in male Swiss-Webster mice. Ibogaine is an alkaloid isolated from the bark of the African shrub, Tabernanthe iboga. Morphine tolerance in mice was developed by two different methods. Mice were rendered tolerant to morphine either by subcutaneous...