Effects of ibogaine on naloxone-precipitated withdrawal in morphine-dependent mice.
Fundamental & clinical pharmacology 1992 B Francés, R Gout, J Cros et al. 46 citations
In naive mice, ibogaine at a tremorigenic dose (30 mg/kg, ip), did not produce antinociception but did potentiate the antinociceptive potency of morphine in the tail-flick test. In morphine-dependent mice, ibogaine did not eliminate withdrawal symptoms but significantly increased the number of repetitive vertical jumps induced by naloxone, whatever the duration of the chronic morphine...