Journal of Clinical Laboratory Analysis
May 26, 2017
Patrick C. Dolder, Matthias E. Liechti, Katharina Rentsch
31 citations
Background Lysergic acid diethylamide ( LSD ) is a widely used recreational drug. The aim of this study was to develop and validate a liquid chromatography tandem mass spectrometry ( LC ‐ MS / MS ) method for the quantification of LSD , iso‐ LSD , 2‐oxo‐3‐hydroxy LSD (O‐H‐ LSD ), and nor‐ LSD in plasma samples from 24 healthy subjects after controlled administration of 100 μg LSD in a clinical...
Clinical Pharmacokinetics
February 14, 2017
Patrick C. Dolder, Yasmin Schmid, Andrea E. Steuer et al.
134 citations
BACKGROUND AND OBJECTIVE: Lysergic acid diethylamide (LSD) is used recreationally and in clinical research. The aim of the present study was to characterize the pharmacokinetics and exposure-response relationship of oral LSD. METHODS: We analyzed pharmacokinetic data from two published placebo-controlled, double-blind, cross-over studies using oral administration of LSD 100 and 200 µg in 24 and...
Journal of Analytical Toxicology
2017
Adrian Stoller, Patrick C. Dolder, Michael Bodmer et al.
19 citations
2,5-Dimethoxy-4(n)-propylphenethylamine (2C-P) is a synthetic phenethylamine derivative belonging to the large family of the so-called 2C drugs. These compounds can differ significantly in receptor affinity, potency and duration of action, and an important structural difference is the ligand in the 4 position of the phenyl ring, such as propyl in 2C-P or bromine in...
BMC pharmacology & toxicology
May 26, 2016
Evangelia Liakoni, Patrick C. Dolder, Katharina Rentsch et al.
24 citations
Although the recreational use of psychoactive substances is common there is only limited systematic collection of data on acute drug toxicity or hospital presentations, in particular regarding novel psychoactive substances (NPS) that have emerged on the illicit market in the last years. We included all cases presenting at the emergency department (ED) of the University Hospital of Basel,...
Journal of Neuroendocrinology
February 6, 2016
Petra Strajhar, Yasmin Schmid, Evangelia Liakoni et al.
129 citations
Lysergic acid diethylamide (LSD) is a serotonin 5‐hydroxytryptamine‐2A (5‐HT 2A ) receptor agonist that is used recreationally worldwide. Interest in LSD research in humans waned after the 1970s, although the use of LSD in psychiatric research and practice has recently gained increasing attention. LSD produces pronounced acute psychedelic effects, although its influence on plasma steroid levels...
The International Journal of Neuropsychopharmacology
June 24, 2015
Patrick C. Dolder, Yasmin Schmid, Manuel Haschke et al.
110 citations
These first data on the pharmacokinetics and concentration-effect relationship of oral lysergic acid diethylamide are relevant for further clinical studies and serve as a reference for the assessment of intoxication with lysergic acid diethylamide.
Annals of emergency medicine
July 1, 2012
Katharina E Hofer, Bettina Grager, Daniel Müller et al.
Methoxetamine, the N-ethyl derivative of ketamine, is a novel recreational drug that is not at present subject to restrictive regulations in most countries. To our knowledge, no case of methoxetamine abuse has been published to date in the scientific literature, and the only sources of information are illegal drug users' Web discussion forums. We report the first case of analytically confirmed...