With the increasing competition in elite sports, pre-competition anxiety has become increasingly prevalent among high-level competitive athletes, and high levels of such anxiety may impair sports performance and threaten athletes' psychological health. Traditional psychological interventions (e.g., cognitive-behavioral therapy) are often poorly accepted and costly; however, pre-competition...
Ketamine and esketamine have demonstrated rapid, short-term antidepressant effects in major depressive disorder (MDD), but their relative safety remains unclear. This review aims to update the evidence on the safety of two agents for MDD and indirectly compare their safety and tolerability. We systematically searched PubMed, PsycINFO, Embase, and Cochrane databases up to 1 May 2025. Eligible...