Journal of Pharmaceutical and Biomedical Analysis
August 15, 2025
Zhen Zhang, Yan Shi, Meiting Lin et al.
Ketamine, which possesses important anesthesia and antidepressant properties, has been used clinically in its racemate form. In the 1990s, the single enantiomer S-ketamine began to be used for clinical use. In 2019, an antidepressant S-ketamine hydrochloride nasal spray hit the market. Therefore, a method for chiral analysis of ketamine is particularly important, as this could reveal the types...
Fa yi xue za zhi
June 25, 2024
Jin-Ting Liu, Li-Ying Zhou, Jia-Hong Xiang et al.
Piperazines are a class of new psychoactive substances with hallucinogenic effects that affect the central nervous system by affecting the level of monoamine neurotransmitters. Abuse of piperazines will produce stimulating and hallucinogenic effects, accompanied by headache, dizziness, anxiety, insomnia, vomiting, chest pain, tachycardia, hypertension and other adverse reactions, and may even...
Journal of Pharmaceutical and Biomedical Analysis
September 20, 2023
Ziyi Li, Zehong Li, Wanting Xie et al.
13 citations
Phencyclidine (PCP) is a frequently abused dissociative agent. It causes confusion, increased tendencies toward violence, and concentration-dependent cytotoxicity after entry into the body. The parent nucleus of phencyclidine-type substances is arylcyclohexylamine, which is easy to modify; therefore, abusers and dealers can readily synthesize substitutes beyond the drug control catalog. An...
Drug Testing and Analysis
March 21, 2022
Wenya Zhai, Le Li, Junbo Zhao et al.
5 citations
Abstract 4‐Acetoxy‐ N , N ‐dimethyltryptamine (4‐AcO‐DMT, psilacetin, O ‐acetylpsilocin) is a synthetic tryptamine with psychedelic properties. Psilacetin may also act as precursor drug of psilocin, similar to psilocybin, but little is known about its metabolism. In this study, the phase I and phase II in vitro metabolism of 4‐AcO‐DMT was investigated with pooled human liver microsomes, and the...
Journal of Chromatography B
March 2, 2022
Shuo Yang, Yan Shi, Zhuonan Chen et al.
13 citations
Mescaline, a natural alkaloid found in the peyote cactus (Lophophora williamsii) in the Americas, has gradually become a drug of abuse in China because of its psychedelic properties. Its intake may lead to hallucinations and confusion or even be life-threatening. Mescaline is classified as a class Ⅰ psychotropic drug in China, which means its use in medicine or scientific research is under...
Forensic Science International
April 20, 2021
Mengxi Liu, Huan Yang, Jing Hu et al.
14 citations
Ayahuasca is a psychoactive beverage widely used in religious ceremonies in Amazonia. Dimethyltryptamine is the main active compound of ayahuasca. Dimethyltryptamine has many hazardous effects, including hallucinations. In the present study, a fast and reliable UPLC-MS/MS method was developed and validated for the quantitation of dimethyltryptamine in hair samples. Twenty-milligram hair samples...
Forensic Toxicology
February 2, 2021
Liying Zhou, Ping Xiang, Di Wen et al.
13 citations
Abstract Purpose In this study, we developed a very sensitive method for quantitative analysis of psilocin and psilocybin in hair samples of magic mushroom consumers. Methods The analyses were performed with pretreatments of samples, followed by ultra-high pressure liquid chromatography (LC) connected to a Q-Trap type tandem mass spectrometry (MS/MS). For LC, mobile phase (A) consisted of 0.1%...
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences
November 30, 2020
Yan Shi, Roujia Wang, Shuai Yuan et al.
Tryptamines are hallucinogenic substances many of which have appeared recently as novel psychoactive substances (NPS). Herein, we describe the establishment of a rapid UHPLC-MS/MS quantitative method for the targeted screening of 16 tryptamines of abuse in hair. Twenty milligram pieces of hair were pulverized below 4 °C in 0.5 mL of deionized water containing 0.1% formic acid and an internal...
Forensic Science International
November 1, 2019
Roujia Wang, Ping Xiang, Zhiguo Yu et al.
5-Methoxy-N,N-diisopropyltryptamine (5-MeO-DiPT) is a designer hallucinogen that is a synthetic tryptamine derivative. It is highly abused and is involved in criminal activities because of its psychotropic properties. Herein, we presented an UHPLC-MS/MS method allowing for the qualitative and quantitative determination of 5-MeO-DiPT in human hair. The hair was first decontaminated and then cut...