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Magdaléna Vágnerová

4 papers in the library · 4 citations · publishing 2024-2025

Papers

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Hexahydrocannabinol: pharmacokinetics, systemic toxicity, and acute behavioral effects in Wistar rats.

The International Journal of Neuropsychopharmacology August 1, 2025 Klára Šíchová, Barbara Mallarino, Lucie Janeckova et al. 1 citation

Hexahydrocannabinol (HHC) is a new psychoactive substance known for its mind-altering effects and temporary legal status. It is widely used in parts of the Europe and United Kingdom as a legal alternative to ∆9-tetrahydrocannabinol, yet little research has explored its effects and safety. This study examined how HHC is processed in the body, its toxicity, and its impact on behavior in male...

DOI: 10.1093/ijnp/pyaf041 (opens in new tab) Full text (opens in new tab) Acute toxicity Behavior Hexahydrocannabinol Pharmacokinetics +1

The acute effects of methoxphenidine on behaviour and pharmacokinetics profile in animal model.

Progress in Neuro-Psychopharmacology and Biological Psychiatry March 20, 2025 Kristýna Štefková-mazochová, Hynek Danda, Vladimír Mazoch et al. 3 citations

Methoxphenidine (MXP) is classified as a new psychoactive substance that has recently emerged on the illicit drug market. Understanding the pharmacological and behavioural profiles of newly emerging drugs is essential for a better understanding of their psychotropic effects and potential toxicity. Therefore, in this study, we investigated a broad range of effects of acute MXP administration:...

DOI: 10.1016/j.pnpbp.2025.111285 (opens in new tab) Full text (opens in new tab) Methoxphenidine Pharmacokinetics Systemic toxicity Wistar rats +7

METHOXPHENIDINE, A DESIGNER DRUG OR A POSSIBLE ROUTE FOR RESEARCH TO DEPRESSION TREATMENT?

The International Journal of Neuropsychopharmacology February 12, 2025 *Bronislav Jurásek, Magdaléna Vágnerová, Hana Walaská et al.

Abstract Background Methoxphenidine (MXP) is a new psychoactive substance that belongs to the group of arylethylamines. Even though MXP has a different pharmacophore than ketamine, both of these substances belong to the dissociatives. To date, MXP has been associated with several intoxications and despite it being banned in most countries it is still available over the internet.1 Aims &...

Hexahydrocannabinol (HHC): pharmacokinetics, systemic toxicity, and acute behavioural effects in Wistar rats.

October 2, 2024 Klára Šíchová, Barbara Mallarino, Lucie Janeckova et al.

Background and purpose: Hexahydrocannabinol (HHC) is a novel psychoactive substance that has gained attention due to its psychotropic effects and temporary legal status. It is widely abused in several EU and US countries, where it serves as a legal and easily accessible alternative to ∆ 9 -tetrahydrocannabinol (∆ 9 -THC). Despite its widespread use, few studies have examined its in vivo effects...

DOI: 10.22541/au.172786658.80817958/v1 (opens in new tab) Pharmacokinetics Toxicity Pharmacology