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Martin Šíma

3 papers in the library · 4 citations · publishing 2024-2025

Papers

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Hexahydrocannabinol: pharmacokinetics, systemic toxicity, and acute behavioral effects in Wistar rats.

The International Journal of Neuropsychopharmacology August 1, 2025 Klára Šíchová, Barbara Mallarino, Lucie Janeckova et al. 1 citation

Hexahydrocannabinol (HHC) is a new psychoactive substance known for its mind-altering effects and temporary legal status. It is widely used in parts of the Europe and United Kingdom as a legal alternative to ∆9-tetrahydrocannabinol, yet little research has explored its effects and safety. This study examined how HHC is processed in the body, its toxicity, and its impact on behavior in male...

DOI: 10.1093/ijnp/pyaf041 (opens in new tab) Full text (opens in new tab) Acute toxicity Behavior Hexahydrocannabinol Pharmacokinetics +1

The acute effects of methoxphenidine on behaviour and pharmacokinetics profile in animal model.

Progress in Neuro-Psychopharmacology and Biological Psychiatry March 20, 2025 Kristýna Štefková-mazochová, Hynek Danda, Vladimír Mazoch et al. 3 citations

Methoxphenidine (MXP) is classified as a new psychoactive substance that has recently emerged on the illicit drug market. Understanding the pharmacological and behavioural profiles of newly emerging drugs is essential for a better understanding of their psychotropic effects and potential toxicity. Therefore, in this study, we investigated a broad range of effects of acute MXP administration:...

DOI: 10.1016/j.pnpbp.2025.111285 (opens in new tab) Full text (opens in new tab) Methoxphenidine Pharmacokinetics Systemic toxicity Wistar rats +7

Hexahydrocannabinol (HHC): pharmacokinetics, systemic toxicity, and acute behavioural effects in Wistar rats.

October 2, 2024 Klára Šíchová, Barbara Mallarino, Lucie Janeckova et al.

Background and purpose: Hexahydrocannabinol (HHC) is a novel psychoactive substance that has gained attention due to its psychotropic effects and temporary legal status. It is widely abused in several EU and US countries, where it serves as a legal and easily accessible alternative to ∆ 9 -tetrahydrocannabinol (∆ 9 -THC). Despite its widespread use, few studies have examined its in vivo effects...

DOI: 10.22541/au.172786658.80817958/v1 (opens in new tab) Pharmacokinetics Toxicity Pharmacology