bioRxiv
April 21, 2026
A. Liardi, Daniel Bor, Fernando E. Rosas et al.
preprint
Recent advances have shown that the complexity of neural signals tracks global states of consciousness, such as wakefulness versus sleep. However, it is still unclear to what extent neural complexity reflects fine-grained changes in conscious content within the same global state. Here, we investigate how the complexity of brain signals is affected by increased perceptual clarity of a stimulus....
Cell Reports
July 22, 2025
George Blackburne, Rosalind McAlpine, Marco S. Fabus et al.
10 citations
5-methoxy-N,N-dimethyltryptamine (5-MeO-DMT) is a psychedelic drug known for its uniquely profound effects on consciousness; however, it remains unknown how it affects the brain. We collected electroencephalography (EEG) data of 29 healthy individuals before and after inhaling a high dose (12-mg) of vaporized synthetic 5-MeO-DMT. We replicate results from rodents showing amplified low-frequency...
bioRxiv (Cold Spring Harbor Laboratory)
October 7, 2024
George Blackburne, Rosalind McAlpine, Marco S. Fabus et al.
8 citations
preprint
Abstract 5-methoxy-N,N-dimethyltryptamine (5-MeO-DMT) is a psychedelic drug known for its uniquely profound effects on subjective experience, reliably eradicating the perception of time, space, and the self. However, little is known about how this drug alters large-scale brain activity. We collected naturalistic electroencephalography (EEG) data of 29 healthy individuals before and after...
George Blackburne, Alberto Liardi, Jeremy I Skipper et al.
preprint
The relationship between subjectivity and its substrate can be understood via the notion of compatibilist emergence, accounting for the plurality of ways nature can host new dynamical laws at higher scales. We discuss how the autopoietic character of life may require and promote the kind of emergence necessary, albeit not sufficient, for consciousness.