When the psychedelic state’s over: limited evidence for persistent neurophysiological changes in naturalistic psychedelic users
bioRxiv (Cold Spring Harbor Laboratory) April 2, 2026 Maja Wójcik, Paweł Orłowski, Stanisław Adamczyk et al.
Abstract Background Contemporary research indicates that psychedelics induce notable neurophysiological changes, some lasting weeks to months after a single dose. However, most evidence derives from acute administration studies and limited post-acute follow-ups. Long-term naturalistic psychedelic users remain critically underexamined, yet may exhibit distinct neurobiological profiles informing...