E R Butelman

Nitric oxide synthase inhibitors produce phencyclidine-like behavioral effects in pigeons.

Brain Research April 9, 1996 D C Jewett, E R Butelman, J H Woods

The present study assessed the ability of nitric oxide synthase (NOS) inhibitors to produce PCP-like behavioral effects in pigeons. Food-restricted pigeons were trained to discriminate between PCP (1.0 mg/kg, i.m.) from saline in a two-key operant procedure. NOS inhibitors 7-nitroindazole (7-NI) and N omega-nitro-L-arginine methyl ester (L-NAME) produced PCP-like discriminative stimulus...