Phencyclidine and genetic animal models of schizophrenia developed in relation to the glutamate hypothesis.
Methods and findings in experimental and clinical pharmacology May 1, 2007 Takeshi Enomoto, Y Noda, Toshitaka Nabeshima
In humans, phencyclidine (PCP), a noncompetitive N-methyl-D-aspartate (NMDA) receptor antagonist, reproduces a schizophrenia-like psychosis including positive symptoms, negative symptoms and cognitive dysfunction. Thus, PCP-treated animals have been utilized as an animal model of schizophrenia. PCP-treated animals exhibit hyperlocomotion as an index of positive symptoms, and a social behavioral...