Role of nitric oxide in the development of tolerance and sensitization to behavioural effects of phencyclidine in mice.
British Journal of Pharmacology April 1996 Y Noda, K Yamada, Y Komori et al.
1. To determine whether nitric oxide (NO) was involved in tolerance and sensitization to the effects of phencyclidine (PCP), we examined NO synthase activity and the number of NADPH-diaphorase (NADPH-d)-positive cells in discrete brain regions of saline-, acute PCP- and repeated PCP-treated mice. We also investigated the effects of a NO synthase inhibitor, NG-nitro-L- arginine methyl ester...