Brain regions mediating alpha3beta4 nicotinic antagonist effects of 18-MC on methamphetamine and sucrose self-administration.
European Journal of Pharmacology October 1, 2008 Stanley D Glick, Elizabeth M Sell, Isabelle M Maisonneuve
The novel iboga alkaloid congener 18-methoxycoronaridine (18-MC) is a putative anti-addictive agent that has been shown, in rats, to decrease the self-administration of several drugs of abuse. Previous work has established that 18-MC is a potent antagonist at alpha3beta4 nicotinic receptors. Because high densities of alpha3beta4 nicotinic receptors occur in the medial habenula and the...
DOI: 10.1016/j.ejphar.2008.09.038 (opens in new tab)
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Ibogaine
Brain
Tegmentum mesencephali
Amygdala
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