3,4-Methylenedioxymethamphetamine (MDMA), commonly known as Ecstasy, is a psychoactive substance used for recreational purposes. This study used a stereoselective method based on high-performance liquid chromatography coupled with triple quadrupole mass spectrometry (HPLC-MS/MS) to quantify MDMA and 3,4-methylenedioxyamphetamine (MDA) enantiomers in human oral fluid (OF). Samples were collected...
Recently we published in this journal an enantioselective high-performance liquid chromatography-tandem mass spectrometry (LC-MS/MS) method for the quantitative determination of 3,4-methylenedioxymethamphetamine (MDMA) and its major phase-1 metabolites, 4-hydroxy-3-methoxyamphetamine (HMA), 4-hydroxy-3-methoxymethamphetamine (HMMA) and 3,4-methylenedioxyamphetamine (MDA) in human plasma, sweat,...
ABSTRACT Background 4-Hydroxy-N,N-methylpropyltryptamine (4-OH-MPT) is a psychedelic tryptamine whose use is regulated in several countries. Due to unspecific effects, consumption can be ascertained only through toxicological analyses. However, the trace amounts of tryptamines are usually challenging to detect in biological samples. 4-OH-MPT metabolism was characterized to identify optimal...