Journal of Analytical Toxicology
March 15, 2026
Aurora Balloni, Sarah M.r. Wille, Giorgia Sprega et al.
3,4-Methylenedioxymethamphetamine (MDMA), commonly known as Ecstasy, is a psychoactive substance used for recreational purposes. This study used a stereoselective method based on high-performance liquid chromatography coupled with triple quadrupole mass spectrometry (HPLC-MS/MS) to quantify MDMA and 3,4-methylenedioxyamphetamine (MDA) enantiomers in human oral fluid (OF). Samples were collected...
Journal of Pharmaceutical and Biomedical Analysis
June 15, 2024
Giorgia Sprega, Giorgi Kobidze, Alfredo Fabrizio Lo Faro et al.
4 citations
Recently we published in this journal an enantioselective high-performance liquid chromatography-tandem mass spectrometry (LC-MS/MS) method for the quantitative determination of 3,4-methylenedioxymethamphetamine (MDMA) and its major phase-1 metabolites, 4-hydroxy-3-methoxyamphetamine (HMA), 4-hydroxy-3-methoxymethamphetamine (HMMA) and 3,4-methylenedioxyamphetamine (MDA) in human plasma, sweat,...
Journal of Pharmaceutical and Biomedical Analysis
January 20, 2024
Alfredo Fabrizio Lo Faro, Giorgia Sprega, Diletta Beradinelli et al.
14 citations
In the present study enantioselective high-performance liquid chromatography-tandem mass spectrometry (LC-MS/MS) methods were developed for the quantitative determination of 3,4-methylenedioxy-methamphetamine (MDMA) and its major phase-1 metabolites 4-hydroxy-3-methoxyamphetamine (HMA), 4-hydroxy-3-methoxymethamphetamine (HMMA) and 3,4-methylenedioxyamphetamine (MDA) in human plasma, sweat,...
International Journal of Molecular Sciences
November 23, 2022
Lourdes Poyatos, Alfredo Fabrizio Lo Faro, Diletta Berardinelli et al.
22 citations
The aim of this study is to define, for the first time, human methylone and HMMC plasma pharmacokinetics following controlled administration of 50–200 mg methylone to 12 male volunteers. A new LC-MS/MS method was validated to quantify methylone, MDMA, and their metabolites in plasma. The study was a randomized, cross-over, double-blinded and placebo-controlled study, with a total of 468 plasma...
International Journal of Molecular Sciences
December 4, 2020
Sara Malaca, Alfredo Fabrizio Lo Faro, Alice Tamborra et al.
48 citations
Our understanding of tryptamines is poor due to the lack of data globally. Tryptamines currently are not part of typical toxicology testing regimens and their contribution to drug overdoses may be underestimated. Although their prevalence was low, it is increasing. There are few published data on the many new compounds, their mechanisms of action, onset and duration of action, toxicity, signs...
Journal of Pharmaceutical and Biomedical Analysis
February 5, 2020
Alfredo Fabrizio Lo Faro, Annagiulia Di Trana, Nunzia La Maida et al.
45 citations
New psychoactive substances (NPS) can be divided into two main groups: synthetic molecules and active principles of natural origin. With respect to this latter group, a wide range of alkaloids contained in plants, mainly from Asia and South America, can be included in the class of NPS of natural origin. The majority NPS of natural origin presents stimulant and/or hallucinogenic effects (e.g....