Journal of Analytical Toxicology
March 15, 2026
Aurora Balloni, Sarah M.r. Wille, Giorgia Sprega et al.
3,4-Methylenedioxymethamphetamine (MDMA), commonly known as Ecstasy, is a psychoactive substance used for recreational purposes. This study used a stereoselective method based on high-performance liquid chromatography coupled with triple quadrupole mass spectrometry (HPLC-MS/MS) to quantify MDMA and 3,4-methylenedioxyamphetamine (MDA) enantiomers in human oral fluid (OF). Samples were collected...
Journal of Pharmaceutical and Biomedical Analysis
June 15, 2024
Giorgia Sprega, Giorgi Kobidze, Alfredo Fabrizio Lo Faro et al.
4 citations
Recently we published in this journal an enantioselective high-performance liquid chromatography-tandem mass spectrometry (LC-MS/MS) method for the quantitative determination of 3,4-methylenedioxymethamphetamine (MDMA) and its major phase-1 metabolites, 4-hydroxy-3-methoxyamphetamine (HMA), 4-hydroxy-3-methoxymethamphetamine (HMMA) and 3,4-methylenedioxyamphetamine (MDA) in human plasma, sweat,...
Journal of Pharmaceutical and Biomedical Analysis
January 20, 2024
Alfredo Fabrizio Lo Faro, Giorgia Sprega, Diletta Beradinelli et al.
14 citations
In the present study enantioselective high-performance liquid chromatography-tandem mass spectrometry (LC-MS/MS) methods were developed for the quantitative determination of 3,4-methylenedioxy-methamphetamine (MDMA) and its major phase-1 metabolites 4-hydroxy-3-methoxyamphetamine (HMA), 4-hydroxy-3-methoxymethamphetamine (HMMA) and 3,4-methylenedioxyamphetamine (MDA) in human plasma, sweat,...
International Journal of Molecular Sciences
November 23, 2022
Lourdes Poyatos, Alfredo Fabrizio Lo Faro, Diletta Berardinelli et al.
22 citations
The aim of this study is to define, for the first time, human methylone and HMMC plasma pharmacokinetics following controlled administration of 50–200 mg methylone to 12 male volunteers. A new LC-MS/MS method was validated to quantify methylone, MDMA, and their metabolites in plasma. The study was a randomized, cross-over, double-blinded and placebo-controlled study, with a total of 468 plasma...