Steven D Pratscher, PhD, Lloyd Lalande, PhD, Mark A Lumley, PhD, Irene M Estores, MD, Adam W Hanley, PhD, Kimberly T Sibille, PhD, Roger B Fillingim, PhD;
Prolonged exposure (PE) therapy is effective for PTSD, yet dropout and partial response remain concerning. Preclinical and human studies suggest Δ9-tetrahydrocannabinol (THC) enhances fear extinction and recall through brain cannabinoid receptor activation in fear processing. Examine whether synthetic THC (dronabinol) augments PE effectiveness. Double-blind, placebo-controlled, trial with...