The Pain Relief for OsteoArthritis through Combined Treatment (PROACT) was a proof-of-principle mechanistic randomized controlled trial to examine the effects of Breathing and Attention Training (BAT), and transcranial direct current stimulation (tDCS) on pain modulatory balance, pain-related brain function, and clinical pain in middle-aged to older adults with knee osteoarthritis (OA)....
Steven D Pratscher, PhD, Lloyd Lalande, PhD, Mark A Lumley, PhD, Irene M Estores, MD, Adam W Hanley, PhD, Kimberly T Sibille, PhD, Roger B Fillingim, PhD;
Mindfulness-based interventions, such as mindfulness-based stress reduction (MBSR), are efficacious mind-body treatments for chronic pain, though their modest effect sizes suggest room for improvement. Notably, recent studies indicate that mindfulness meditation does not engage the endogenous opioid system, which plays an important role in analgesia. Therefore, exploring the combination of a...
BACKGROUND: Chronic pain is a major source of human suffering, and chronic low back pain (cLBP) is among the most prevalent, costly, and disabling of pain conditions. Due to the significant personal and societal burden and the complex and recurring nature of cLBP, self-management approaches that can be practiced at home are highly relevant to develop and test. The respiratory system is one of...
Frontiers in Pain Research2023Ramakrishnan Mani, Divya Bharatkumar Adhia, Sharon Awatere et al.3 citations
Knee osteoarthritis (OA) is a chronic secondary musculoskeletal pain condition resulting in disability, reduced quality of life, and high societal costs. Pain associated with knee OA is linked to increased sensitivity in sensory, cognitive, and emotional areas of the brain. Self-regulation training targeting brain functioning related to pain experience could reduce pain and its associated...