Brain, behavior, and immunity
July 5, 2026
Bruno Pedraz-Petrozzi, Marta Marszalek-Grabska, Emilia Fornal et al.
Treatment-resistant depression (TRD) remains a major clinical challenge, with highly variable responses to ketamine. Immune activation characterizes a subset of patients with TRD. The kynurenine pathway (KP), which integrates immunometabolic signals with glutamatergic neurotransmission, may provide candidate biomarkers to inform personalized treatment. We investigated whether KP metabolites and...
Frontiers in Psychiatry
2024
Bruno Pedraz-Petrozzi, Moritz Spangemacher, Anton Deicher et al.
6 citations
Neuroinflammatory processes in depression are associated with treatment resistance to conventional antidepressants. Ketamine is an effective new therapeutic option for treatment-resistant depression (TRD). Its well-established immunomodulatory properties are hypothesized to mediate its antidepressant effect. In this context, higher levels of inflammation may predict a better treatment response....
Clinical Case Reports
March 1, 2023
Bruno Pedraz-Petrozzi, Michael Deuschle, Maria Gilles
We admitted a 42-year-old patient with severe treatment-resistant depression and with psychiatric comorbidities. The patient attempted suicide 5 weeks after admission. Subsequently, we initiated dextromethorphan/bupropion based on prior evidence. As a result, the patient demonstrated an improvement in mood symptoms and a reduction in suicide risk, leading to her discharge.
Neuroscience Applied
2022
Lea J. Mertens, Michael Koslowski, Felix Betzler et al.
40 citations
Psychedelics such as psilocybin have recently gained remarkable interest in both the specialist literature and the lay press because studies suggest that these substances may have great therapeutic potential in various psychiatric disorders, including major depression. However, clinical trials with psychedelic drugs pose particular methodological challenges to researchers, some of which differ...
University Library Heidelberg
May 30, 2020
Michael Schredl, Maria Gilles, Isabell Wolf et al.
2 citations
Dream recall frequencies exhibit large inter-individual differences, ranging from recalling a dream almost every morning to recalling a dream almost never. Although dream recall has been conceptualized as a stable trait, longitudinal studies in this area are scarce. Within the framework of a complex study, 279 women (mean age: 31.76 ± 4.73 yrs.) completed a brief sleep questionnaire three times...
BMC Pregnancy and Childbirth
November 9, 2016
Michael Schredl, Maria Gilles, Isabell Wolf et al.
Pregnancy-related dreams are often found in pregnant women but also the number of negatively toned dreams seems to be increased in this challenging phase of a woman's life. Nightmare frequency and subjectively experienced stress was elicited via questionnaires. The mothers-to-be were approached during their application visit about 4-8 weeks prior to delivery in three obstetric hospitals. The...