Background: Treatment-resistant depression (TRD) represents a major clinical challenge, being associated with high morbidity, increased suicide risk, and substantial socioeconomic burden. The need for rapidly acting interventions has driven the development of rapid-acting antidepressants (RAADs), such as ketamine, esketamine, and scopolamine. This study aimed to systematically review the...
Abstract Fibromyalgia (FM) is a chronic pain syndrome characterized by widespread musculoskeletal pain, fatigue, and cognitive symptoms. Despite current therapeutic strategies, many patients continue to experience the poor outcomes. Ayahuasca, a traditional Amazonian brew containing N, N-dimethyltryptamine (DMT), and β-carboline alkaloids, has shown antinociceptive and anti-inflammatory...
Fibromyalgia (FM) subjects are treated with antidepressant agents; in most cases, these drugs lose efficacy or have adverse effects. Ketamine is an anesthetic drug used in FM in some studies. This article aims to systematically review the safety and efficacy of ketamine in fibromyalgia (FM) patients. We systematically searched articles on FM and ketamine published at Pubmed from 1966 to 2021....