Thomas Graven‐nielsen

2 papers in the library · 409 citations · publishing 2000-2023

Papers

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Pain-free default mode network connectivity contributes to tonic experimental pain intensity beyond the role of negative mood and other pain-related factors.

European Journal of Pain May 31, 2023 Najah Alhajri, Shellie Ann Boudreau, André Mouraux et al.

Background: Alterations in the default mode network (DMN) connectivity across pain stages suggest a possible DMN involvement in the transition to persistent pain. Aim: This study examined whether pain-free DMN connectivity at lower alpha oscillations (8-10 Hz) accounts for a unique variation in experimental peak pain intensity beyond the contribution of factors known to influence pain...

DOI: 10.1002/ejp.2141 Full text Default mode network Gyrus cinguli Neural pathways Humans +6

Ketamine reduces muscle pain, temporal summation, and referred pain in fibromyalgia patients

Pain April 1, 2000 Thomas Graven‐nielsen, Sally Kendall, Karl G. Henriksson et al. 409 citations

Central mechanisms related to referred muscle pain and temporal summation of muscular nociceptive activity are facilitated in fibromyalgia syndrome (FMS) patients. The present study assessed the effects of an NMDA-antagonist (ketamine) on these central mechanisms. FMS patients received either i.v. placebo or ketamine (0.3 mg/kg, Ketalar((R))50% decrease in pain intensity at rest by active drug...

DOI: 10.1016/s0304-3959(99)00308-5 Ketamine Hypertonic saline Anesthesia Fibromyalgia +6