Ketamine reduces muscle pain, temporal summation, and referred pain in fibromyalgia patients
Pain April 1, 2000 Thomas Graven‐nielsen, Sally Kendall, Karl G. Henriksson et al. 409 citations
Central mechanisms related to referred muscle pain and temporal summation of muscular nociceptive activity are facilitated in fibromyalgia syndrome (FMS) patients. The present study assessed the effects of an NMDA-antagonist (ketamine) on these central mechanisms. FMS patients received either i.v. placebo or ketamine (0.3 mg/kg, Ketalar((R))50% decrease in pain intensity at rest by active drug...