Psychotherapy and Psychosomatics
June 19, 2026
Judith Rohde, Tyler M Moore, Kathryn Walker et al.
Ketamine combined with psychotherapy has shown promise in treating posttraumatic stress disorder (PTSD), but predictors of clinical benefit remain unclear. In this systematic review and individual participant data meta-analysis (IPDMA), we examined patient- and treatment-level predictors of PTSD symptom change after combined treatment. Eligible studies combined ketamine with psychotherapy in...
Journal of Psychoactive Drugs
October 10, 2025
Mitch Earleywine, Caitlin Holley, Henry A MacConnel et al.
MDMA-assisted therapy (MDMA-AT) for post-traumatic stress disorder (PTSD) shows promise, but attitudes and beliefs about this treatment, especially in symptomatic veterans, remain poorly understood. We sought to explore relevant attitudes in veterans receiving healthcare from Veterans Affairs as a step toward designing relevant surveys or psychoeducation materials for future work. We employed a...
Cognitive and Behavioral Practice
April 1, 2025
M. Earleywine, Henry A MacConnel, Joseph A. de Leo
Metaphors applied in psychedelic-assisted therapy (PAT) influence expectations and outcomes. They might help minimize therapist burnout as well. Nevertheless, relatively few publications address their conscious application, especially within a cognitive behavioral framework. Metaphors in PAT related to journeys, rewiring the brain, and medicines are prevalent, but these approaches may not...
Journal of psychopharmacology (Oxford, England)
2025
Henry A MacConnel, Mitch Earleywine, Steven Radowitz
5 citations
Traditional treatments for post-traumatic stress disorder (PTSD) often show limited success with high dropout. Ketamine, an N-methyl-D-aspartate antagonist known for rapid antidepressant effects, has decreased PTSD symptoms in some studies but not in others. Administering ketamine in ways that parallel psychedelic-assisted treatments-including preparatory, integration, sensory immersion, and...