Rapid and sustained reduction of treatment-resistant PTSD symptoms after intravenous ketamine in a real-world, psychedelic paradigm.
Journal of Psychopharmacology 2025 Henry A MacConnel, Mitch Earleywine, Steven Radowitz 5 citations
Traditional treatments for post-traumatic stress disorder (PTSD) often show limited success with high dropout. Ketamine, an N-methyl-D-aspartate antagonist known for rapid antidepressant effects, has decreased PTSD symptoms in some studies but not in others. Administering ketamine in ways that parallel psychedelic-assisted treatments-including preparatory, integration, sensory immersion, and...
DOI: 10.1177/02698811241286726 (opens in new tab)
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PTSD
Ketamine-assisted psychotherapy
Psychedelic
Kap
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