Progress in Neuro-Psychopharmacology and Biological Psychiatry
April 1, 2022
M. Bove, Stefania Schiavone, Paolo Tucci et al.
Autism Spectrum Disorders (ASD) core symptoms include deficits of social interaction, stereotyped behaviours, dysfunction in language and communication. Beyond them, several additional symptoms, such as cognitive impairment, anxiety-like states and hyperactivity are often occurring, mainly overlapping with other neuropsychiatric diseases. To untangle mechanisms underlying ASD etiology, and to...
Progress in Neuro-Psychopharmacology and Biological Psychiatry
2020
Stefania Schiavone, M. Morgese, M. Bove et al.
Administration in adulthood of subanaesthetic doses of ketamine, an NMDA receptor (NMDA-R) antagonist, is commonly used to induce psychotic-like alterations in rodents. The NADPH oxidase (NOX) derived-oxidative stress has been shown to be implicated in ketamine-induced neurochemical dysfunctions and in the loss of parvalbumin (PV)-positive interneurons associated to the administration of this...
International Clinical Psychopharmacology
September 1, 2011
Silvia Sorce, Stefania Schiavone, Paolo Tucci et al.
The 15th Biennial Winter Workshop in Psychoses, 15–18 November 2009, Barcelona, Spain: DRUG INDUCED PSYCHOSES
Journal of Neuroscience
August 25, 2010
Silvia Sorce, Stefania Schiavone, Paolo Tucci et al.
Subanesthetic doses of NMDA receptor antagonist ketamine induce schizophrenia-like symptoms in humans and behavioral changes in rodents. Subchronic administration of ketamine leads to loss of parvalbumin-positive interneurons through reactive oxygen species (ROS), generated by the NADPH oxidase NOX2. However, ketamine induces very rapid alterations, in both mice and humans. Thus, we have...