Ketamine administration induces early and persistent neurochemical imbalance and altered NADPH oxidase in mice.
Progress in Neuro-Psychopharmacology and Biological Psychiatry 2020 Stefania Schiavone, M. Morgese, M. Bove et al.
Administration in adulthood of subanaesthetic doses of ketamine, an NMDA receptor (NMDA-R) antagonist, is commonly used to induce psychotic-like alterations in rodents. The NADPH oxidase (NOX) derived-oxidative stress has been shown to be implicated in ketamine-induced neurochemical dysfunctions and in the loss of parvalbumin (PV)-positive interneurons associated to the administration of this...