Tolerance to hypothermic and antinoceptive effects of ∆9-tetrahydrocannabinol (THC) vapor inhalation in rats.
Pharmacology, Biochemistry, and Behavior September 2018 Jacques D. Nguyen, Yanabel Grant, Tony M Kerr et al.
A reduced effect of a given dose of ∆9-tetrahydrocannabinol (THC) emerges with repeated exposure to the drug. This tolerance can vary depending on THC dose, exposure chronicity and the behavioral or physiological measure of interest. A novel THC inhalation system based on e-cigarette technology has been recently shown to produce the hypothermic and antinociceptive effects of THC in rats. To...
DOI: 10.1016/j.pbb.2018.07.007 (opens in new tab)
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Cannabis
Marijuana
E-cigarette
Hypothermia
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