JMIR Research Protocols
June 12, 2026
Chelsea J Siwik, Hallie Tankha, Jacob D Hill et al.
Abstract BackgroundMigraine ranks among the leading causes of disability worldwide. Comorbid depressive symptoms are highly prevalent in patients with migraine and are associated with worsened pain severity, greater migraine-related disability, and poorer migraine prognosis. Despite this burdensome comorbidity, the treatment of these co-occurring disorders has rarely been studied. While...
February 16, 2026
Chelsea J Siwik, Hallie Tankha, Jacob D Hill et al.
BACKGROUND Migraine ranks among the leading causes of disability worldwide. Comorbid depressive symptoms are highly prevalent in patients with migraine and are associated with worsened pain severity, greater migraine-related disability, and poorer migraine prognosis. Despite this burdensome comorbidity, the treatment of these co-occurring disorders has rarely been studied. While...
Current Pain and Headache Reports
September 16, 2025
Toby Dresdner, Elizabeth K. Seng
This goal of this paper is to identify the need to report adverse events (AEs) in mindfulness-based interventions (MBIs) for migraine and highlight conceptual issues related to their reporting. This paper reviews the benefits and AEs in MBIs broadly and considers their application to a migraine population. Due to a lack of standardized protocol for measuring and reporting, there is little...
Headache: The Journal of Head and Face Pain
April 1, 2025
Elizabeth K. Seng, Jacob D Hill, Annie Kate Reeder et al.
This study was an open-label single-arm clinical trial evaluating the fidelity, feasibility, acceptability, and clinical signal of abbreviated mindfulness-based cognitive therapy (MBCT-brief) delivered either via telephone (MBCT-T) or by video conferencing (MBCT-V) for people with migraine and comorbid depressive symptoms. Migraine is commonly comorbid with elevated depressive symptoms. MBCT...
Journal of Behavioral Medicine
June 1, 2024
Rachel D Best, Ali Ozmeral, Amy S. Grinberg et al.
Migraine is one of the leading causes of disability worldwide. Third wave therapies, such as Mindfulness Based Cognitive Therapy for Migraine (MBCT-M), have proven efficacious in reducing headache-related disability. However, research is needed to better understand the change mechanisms involved in these third-wave therapies. Acceptance is a fundamental component of third wave therapies, and...
Headache: The Journal of Head and Face Pain
March 2023
Paige M Estave, Caitlyn Margol, Summerlyn Beeghly et al.
To understand the mechanisms of mindfulness' impact on migraine. Promising mindfulness research demonstrates potential benefit in migraine, but no data-driven model exists from the lived experiences of patients that explains the mechanisms of mindfulness in migraine. Semi-structured qualitative interviews were conducted with adults with migraine who participated in two mindfulness-based stress...
Headache: The Journal of Head and Face Pain
2023
Jessica A Kruse, Elizabeth K. Seng
This study is a secondary analysis evaluating changes in cognitive fusion and pain catastrophizing over 8 weeks of mindfulness-based cognitive therapy for migraine (MBCT-M) intervention versus waitlist/treatment as usual. Migraine is a common disabling neurological condition. MBCT-M combines elements of cognitive behavioral therapy with mindfulness-based approaches and has demonstrated efficacy...
Neurology. Clinical practice
June 2021
Elizabeth K. Seng, Alexandra B Conway, Amy S. Grinberg et al.
Evaluate whether the benefits of Mindfulness-Based Cognitive Therapy for Migraine (MBCT-M) on headache disability differs among people with episodic and chronic migraine (CM). This is a planned secondary analysis of a randomized clinical trial. After a 30-day baseline, participants were stratified by episodic (6-14 d/mo) and CM (15-30 d/mo) and randomized to 8 weekly individual sessions of...
Expert Review of Neurotherapeutics
January 14, 2020
Rebecca Erwin Wells, Elizabeth K. Seng, Robert R Edwards et al.
74 citations
Introduction: Migraine is the second leading cause of disability worldwide, yet many patients are unable to tolerate, benefit from, or afford pharmacological treatment options. Non-pharmacological migraine therapies exist, especially to reduce opioid use, which represents a significant unmet need. Mindfulness-based interventions (MBI) have potential as a non-pharmacological treatment for...
Headache: The Journal of Head and Face Pain
September 26, 2019
Elizabeth K. Seng, Alexandra B. Singer, Christopher Metts et al.
The current Phase 2b study aimed to evaluate the efficacy of mindfulness‐based cognitive therapy for migraine (MBCT‐M) to reduce migraine‐related disability in people with migraine.