JMIR Research Protocols
June 12, 2026
Chelsea J Siwik, Hallie Tankha, Jacob D Hill et al.
Abstract BackgroundMigraine ranks among the leading causes of disability worldwide. Comorbid depressive symptoms are highly prevalent in patients with migraine and are associated with worsened pain severity, greater migraine-related disability, and poorer migraine prognosis. Despite this burdensome comorbidity, the treatment of these co-occurring disorders has rarely been studied. While...
February 16, 2026
Chelsea J Siwik, Hallie Tankha, Jacob D Hill et al.
BACKGROUND Migraine ranks among the leading causes of disability worldwide. Comorbid depressive symptoms are highly prevalent in patients with migraine and are associated with worsened pain severity, greater migraine-related disability, and poorer migraine prognosis. Despite this burdensome comorbidity, the treatment of these co-occurring disorders has rarely been studied. While...
Headache: The Journal of Head and Face Pain
April 1, 2025
Elizabeth K. Seng, Jacob D Hill, Annie Kate Reeder et al.
This study was an open-label single-arm clinical trial evaluating the fidelity, feasibility, acceptability, and clinical signal of abbreviated mindfulness-based cognitive therapy (MBCT-brief) delivered either via telephone (MBCT-T) or by video conferencing (MBCT-V) for people with migraine and comorbid depressive symptoms. Migraine is commonly comorbid with elevated depressive symptoms. MBCT...
Neurology. Clinical practice
June 2021
Elizabeth K. Seng, Alexandra B Conway, Amy S. Grinberg et al.
Evaluate whether the benefits of Mindfulness-Based Cognitive Therapy for Migraine (MBCT-M) on headache disability differs among people with episodic and chronic migraine (CM). This is a planned secondary analysis of a randomized clinical trial. After a 30-day baseline, participants were stratified by episodic (6-14 d/mo) and CM (15-30 d/mo) and randomized to 8 weekly individual sessions of...
Headache: The Journal of Head and Face Pain
September 26, 2019
Elizabeth K. Seng, Alexandra B. Singer, Christopher Metts et al.
The current Phase 2b study aimed to evaluate the efficacy of mindfulness‐based cognitive therapy for migraine (MBCT‐M) to reduce migraine‐related disability in people with migraine.